Dr Mark D. Preston

Selected Publications

Report on the WHO collaborative study to investigate the utility of next generation sequencing (NGS) as a molecular test of virus stocks used in the manufacture of Poliovirus vaccine (Oral)
J. Martin, K. Chumakov, J. Hockley, T. Wilton, L. Crawt, M. Majumdar, E. Mee, B. Valdazo-Gonzalez, NGS Study Group, M. D. Preston, P. Rigsby, B. Charlton
2019 WHO Expert Committee Report

The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis
T.R. Rudd, M.D. Preston, E.A. Yates
2017 Molecular BioSystems 10.1039/C6MB00857G

On a singular initial-value problem for the Navier-Stokes equations
L.E. Fraenkel, M.D. Preston
2015 Mathematika 10.1112/S0025579314000333

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
M.D. Preston, et al.
2014 Nature Communications 10.1038/ncomms5052

PlasmoView: A web-based resourse to visualise global Plasmodium falciparum genomic variation
M.D. Preston, et al.
2013 J. Infectious Diseases 10.1093/infdis/jit812

BSc Mathematics, MSc Multimedia Technology, PhD Mathematics

Experience - Industry

Consultant
Prismea
2020 -
Director of Services
Eagle Genomics
2018 - 2020
IT Consultant
Self-employed
2000 - 2012
IT Manager
SoftBrands Hospitality, USA
2002 - 2003
IT Programer
Madge Networks
1998 - 1999

Experience - Government

Head of Digital Solutions
Medicines and Healthcare product Regulatory Agency
2018
Head of NGS/Bioinformatics
National Institute for Biological Standards and Control
2015 - 2018

Experience - Academia

Research Fellow
London School of Hygiene and Tropical Medicine
2011 - 2015
Research Assistant
University of Bath, Department of Mathematics
2009 - 2011
Research Associate
University of York, Department of Biology
2008 - 2011
Teaching Fellow
University of York, Department of Mathematics
2007 - 2008
PhD Mathematics
University of Reading, Department of Mathematics
2004 - 2007
MSc Multimedia Technology
University of Bath, Department of Computer Science
1999 - 2000
BSc Mathematics
University of Bath, Department of Mathematics
1994 - 1998

Funding

Leverhulme Emeritus Fellowship
University of Bath (awarded to Prof Edward Fraenkel FRS)
2009
Pump-prime Funding
University of York
2008 - 2009
Teaching Award
University of York
2007
EPSRC Doctoral Training
University of Reading
2004 - 2007
Panasonic Trust Fellowship
University of Bath
1999 - 2000

The Use of Next-Generation Sequencing for the Quality Control of Live-Attenuated Polio Vaccines
B. Charlton, J. Hockley, M. Laassri, T. Wilton, L. Crawt, M.D. Preston, NGS Study Group, P. Rigsby, K. Chumakov, J. Martin
2020 Journal of Infectious Diseases 10.1093/infdis/jiaa299

Vaccination of macaques with DNA followed by adenoviral vectors encoding simian immunodeficiency virus (SIV) Gag alone delays infection by repeated mucosal challenge with SIV
N. Almond, N. Berry, R. Stebbings, M.D. Preston, C. Ham, M. Page, D. Ferguson, N. Rose, B. Li, E.T. Mee, M. Hassall, C. Stahl-Hennig, T. Athanasopoulos, T. Papagatsias, S. Herath, A. Benlahrech, G. Dickson, A. Meiser, S. Patterson
2019 Journal of Virology 10.1128/JVI.00606-19

Report on the WHO collaborative study to investigate the utility of next generation sequencing (NGS) as a molecular test of virus stocks used in the manufacture of Poliovirus vaccine (Oral)
J. Martin, K. Chumakov, J. Hockley, T. Wilton, L. Crawt, M. Majumdar, E. Mee, B. Valdazo-Gonzalez, NGS Study Group, M. D. Preston, P. Rigsby, B. Charlton
2019 WHO Expert Committee Report

Clostridium difficile clade 3 (RT023) have a modified cell surface and contain a large transposable island with novel cargo
H.A. Shaw, L. Khodadoost, M.D. Preston, J. Corver, P. Mullany, B.W. Wren
2019 Nature Scientific Reports 10.1038/s41598-019-51628-5

The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics
H.A. Shaw, M.D. Preston, K.E.W. Vendrik, M.D. Cairns, H.P. Browne, R.A. Stabler, M.J.T. Crobach, J. Corver, H. Pituch, A. Ingebretsen, M. Pirmohamed, A. Faulds-Pain, E. Valiente, T.D. Lawley, N.F. Fairweather, E.J. Kuijper, B.W. Wren
2019 Clinical Microbiology and Infection 10.1016/j.cmi.2019.09.004

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria
I.J. Passmore, M.P.M. Letertre, M.D. Preston, I. Bianconi, M.A. Harrison, F. Nasher, H. Kaur, H.A. Hong, S.D. Baines, S.M. Cutting, J.R. Swann, B.W. Wren, L.F. Dawson
2018 PLoS Pathogens 10.1371/journal.ppat.1007191

Pathways-wide genetic risks in Chlamydial infections overlap between tissue tropisms: A genome-wide association scan
C.h. Roberts, S. Ouberg, M.D. Preston, H.J.C. de Vries, M.J. Holland, S.A. Morre
2018 Mediators of Inflammation 10.1155/2018/3434101

Frequent Undetected Ward-Based Methicillin-Resistant Staphylococcus aureus Transmission Linked to Patient Sharing Between Hospitals
O. Tosas Auguet, R.A. Stabler, J. Betley M.D. Preston, M. Dhaliwal, M. Gaunt, A. Ioannou, N. Desai, T. Karadag, R. Batra, J.A. Otter, H. Marbach, T.G. Clark, J.D. Edgeworth
2018 Clinical Infectious Diseases 10.1093/cid/cix901

Comparative genome analysis and global phylogeny of the toxin variant Clostridium difficile PCR ribotype 017 reveals the evolution of two independent sublineages
M.D. Cairns, M.D. Preston, C.L. Hall, D.N. Gerding, P.M. Hawkey, H. Kato, H. Kim, E.J. Kuijper, T.D. Lawley, H. Pituch, S. Reid, B. Kullin, T.V. Riley, K. Solomon, P.J. Tsai, J.S. Weese, R.A. Stabler, B.W. Wren
2017 J. Clinical Microbiology 10.1128/JCM.01296-16

The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis
T.R. Rudd, M.D. Preston, E.A. Yates
2017 Molecular BioSystems 10.1039/C6MB00857G

From FASTQ to Function: In Silico Methods for Processing Next-Generation Sequencing Data
M.D. Preston, R.A. Stabler
2016 Clostridium difficile: Methods and Protocols 10.1007/978-1-4939-6361-4_3

Development of a candidate reference material for adventitious virus detection in vaccine and biologicals manufacturing by deep sequencing
E.T. Mee, M.D. Preston, P.D. Minor, S. Schepelmann, CSS Participants
2016 Vaccine 10.1016/j.vaccine.2015.12.020

Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study
C.h. Roberts, C. S. Franklin, P. Makalo, H. Joof, I. Sarr, O.S. Mahdi, A. Sillah, M. Bah, F. Payne, A.E. Jeffreys, W. Bottomley, A. Natividad, S. Molina-Gonzalez, S.E. Burr, M.D. Preston, D. Kwiatkowski, K.A. Rockett, T.G. Clark, M.J. Burton, D.C.W. Mabey, R. Bailey, I.S. Barros, M.J. Holland
2015 Nature Scientific Reports 10.1038/srep17447

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
S.A. Assefa, C. Lim, M.D. Preston, C.W. Duffy, M.B. Nair, S.A. Adroub, K.A. Kadir, J.M. Goldberg, D.E. Neafsey, P. Divis, T.G. Clark, M.T. Duraisingh, D.J. Conway, A. Pain, B. Singh
2015 Proceedings of the National Academy of Sciences 10.1073/pnas.1509534112

Impact of individual movement and changing resource availability on male-female encounter rates in an herbivorous insect
M.D. Preston, M.L. Forister, J.W. Pitchford, P.A. Armsworth
2015 Ecological Complexity 10.1016/j.ecocom.2015.07.004

Genomic epidemiology of a protracted hospital outbreak caused by a toxin A negative, Clostridium difficile sublineage PCR Ribotype 017 strain in London, England.
M.D. Cairns, M.D. Preston, T.D. Lawley, T.G. Clark, R.A. Stabler, B.W. Wren
2015 J. Clinical Microbiology 10.1128/JCM.00648-15

Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
F. Coll, R. McNerney, M.D. Preston, J.A. Guerra-Assuncaol, A. Warry, G. Hill-Cawthrone, K. Mallard, M. Nair, A. Miranda, A. Alves, J. Perdigao, M. Voveoros, I. Portugal, Z. Hasan, R. Hasan, J.R. Glynn, N. Martin, A. Pain, T.G. Clark
2015 Genome Medicine 10.1186/s13073-015-0164-0

Imputation-based population genetics analysis of Plasmodium falciparum malaria parasites
H. Samad, F. Coll, M.D. Preston, H. Ocholla, R.M. Fairhurst, T.G. Clark
2015 PLoS Genetic 10.1371/journal.pgen.1005131

On a singular initial-value problem for the Navier-Stokes equations
L.E. Fraenkel, M.D. Preston
2015 Mathematika 10.1112/S0025579314000333

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates
H. Ocholla, M.D. Preston, M. Mipando, A.T. Jensen, S. Campino, B. MacInnis, D. Alcock, A. Terlouw, I. Zongo, J-B. Oudraogo, A. Djimda, S.A. Assefa, O. Doumbo, S. Borrmann, A. Nzila, K. Marsh, R.M. Fairhurst, F. Nosten, T.J. Anderson, D.P. Kwiatkowski, A. Craig, T.G. Clark, J. Montgomery
2014 J. Infectious Diseases 10.1093/infdis/jiu349

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains
M.D. Preston, S. Campino, S.A. Assefa, D. Echeverry, H. Ocholla, A. Amambua-Ngwa, L.B. Stewart, D.J. Conway, S. Borrmann, P. Michon, I. Zongo, J-B. Ouedraogo, A. Djimda, O. Doumbo, F. Nosten, A. Pain, T. Bousema, C.J. Drakeley, R.M. Fairhurst, C.J. Sutherland, C. Roper T.G. Clark
2014 Nature Communications 10.1038/ncomms5052

SVAMP: Sequence variation analysis, maps and phylogeny
R. Naeem, L. Hidayah, M.D. Preston, T.G. Clark, A. Pain
2014 Bioinformatics 10.1093/bioinformatics/btu176

PolyTB: A genomic variation map for Mycobacterium tuberculosis
F. Coll, M.D. Preston, J.A. Guerra-Assuncao, G. Hill-Cawthorn, D. Harris, J. Perdigao, M. Viveiros, I. Portugal, F. Drobniewski, S. Gagneux, J.R. Glynn, A. Pain, J. Parkhill, R. McNerney, N. Martin, T.G. Clark
2014 Tuberculosis 10.1016/j.tube.2014.02.005

PlasmoView: A web-based resourse to visualise global Plasmodium falciparum genomic variation
M.D. Preston, S.A. Assefa, H. Ocholla, C.J Sutherland, S. Borrmann, A. Nzila, P. Michon, TT Hien, T Bousema, C.J. Drakeley, I. Zongo, J.B. Ouedraogo, A.A. Djimde, O.K. Doumbo, F. Nosten, R.M. Fairhurst, D.J. Conway, C. Roper, T.G. Clark
2013 J. Infectious Diseases 10.1093/infdis/jit812

Using family-based designs for detecting rare variant disease associations
M.D. Preston, F. Dudbridge
2013 Annals of Human Genetics 10.1111/ahg.12051

EstMoi: Estimating multiplicity of infection using parasite deep sequencing data
S.A. Assefa, M.D. Preston, S. Campino, H. Ocholla, C.J. Sutherland, T.G. Clark
2013 Bioinformatics 10.1093/bioinformatics/btu005

Elucidating Emergence and Transmission of Multidrug-Resistant Tuberculosis in Treatment Experienced Patients by Whole Genome Sequencing
T.G. Clark, K. Mallard, F. Coll, M.D. Preston, S.A. Assefa, D. Harris, S. Ogwang, F. Mumbowa, B. Kirenga, D.M. O'Sullivan, A. Okwera, K.D. Eisenach, M. Joloba, S.D. Bentley, J.J. Ellner, J. Parkhill, E.C. Jones-Lopez, R. McNerney
2013 Plos One 10.1371/journal.pone.0083012

Dystromirs as serum biomarkers for monitoring the disease severity in Duchenne Muscular Dystrophy
I.T. Zaharieva, M. Calissano, M. Scoto, M.D. Preston, S. Cirak, L. Feng, J. Collins, R. Kole, M. Guglieri, V. Straub, K. Bushby, A. Ferlini, J.E. Morgan, F. Muntoni
2013 Plos One 10.1371/journal.pone.0080263

SpolPred: Rapid and accurate prediction of Mycobacterium tuberculosis spoligotypes from short genomic sequences
F. Coll, K. Mallard, M.D. Preston, S. Bentley, J. Parkhill, R. McNerney, N. Martin, T.G. Clark
2012 Bioinformatics 10.1093/bioinformatics/bts544

VarB: A variation browsing tool for polymorphisms derived from next-generation sequence data
M.D. Preston, H.M. Manske et al.
2012 Bioinformatics 10.1093/bioinformatics/bts557

A Nyström method for a boundary value problem arising in unsteady water wave problems
M.D. Preston, S.N. Chandler-Wilde, P.G. Chamberlain
2011 IMA: J. Numerical Analysis 10.1093/imanum/drq009

Evolutionary optimality in stochastic search problems
M.D. Preston, J.W. Pitchford, A.J. Wood
2010 J. Royal Society Interface 10.1098/rsif.2010.0090

An integral equation method for a boundary value problem arising in unsteady water wave problems
M.D. Preston, S.N. Chandler-Wilde, P.G. Chamberlain
2008 J. Integral Equations and Applications 10.1216/JIE-2008-20-1-121

Conferences

Poster: Butterfly mating, Won 3rd Prize in Poster Competition.
M.D. Preston, J.W. Pitchford, P.R. Armsworth, M. Forrister
2012 UCL Computational Life and Medical Sciences Network Annual Symposium, London -

Paper: An integral equation method for a boundary value problem arising in unsteady water wave problems
M.D. Preston, S.N. Chandler-Wilde, P.G. Chamberlain
2005 Proc. of the UKBIM5, Liverpool